There was a decreasing trend in forehead sebum excretion rate in the pomegranate extract group after 4 weeks (-21.9%) compared to an increase in the placebo group (+17.2%), though this was not statistically significant (p=0.14).
No significant differences were seen in cheek sebum production.
The study did not directly examine acne, but the authors suggest the sebum reduction could potentially benefit acne-prone skin, as excess sebum production is associated with acne development.
Chakkalakal, M., Nadora, D., Gahoonia, N., Dumont, A., Burney, W., Pan, A., Chambers, C. J., & Sivamani, R. K. (2022). Prospective Randomized Double-Blind Placebo-Controlled Study of Oral Pomegranate Extract on Skin Wrinkles, Biophysical Features, and the Gut-Skin Axis. Journal of clinical medicine, 11(22), 6724. https://doi.org/10.3390/jcm11226724
# Study 2 (Rehmannia glutinosa leaf extract)
No statistically significant effects on sebum production were reported.
The study focused on acne severity rather than sebum production specifically. The acne severity scores improved more in the treatment group compared to placebo after 4 and 8 weeks.
Srivastava, S., Huang, S. F., & Jagtap, M. S. (2024). Assessment of the Effect of Rehmannia glutinosa Leaf Extract in Maintaining Skin Health: A Proof-of-Concept, Double-Blind, Randomized, Placebo-Controlled Clinical Trial. Clinical, cosmetic and investigational dermatology, 17, 863–875. https://doi.org/10.2147/CCID.S448928
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Study 3 (Terminalia chebula fruit extract)
In subjects with high baseline sebum (>80 μg/cm2), the treatment group had a significant decrease in forehead sebum compared to placebo at 4 weeks (-17% vs +20%, p=0.074) and 8 weeks (-33% vs +29%, p<0.01).
The authors note this 33% reduction is similar to effects seen with oral spironolactone, a medication used to treat acne.
They suggest this warrants further study in populations with higher sebum production like those with acne or seborrheic dermatitis.
Chakkalakal, M., Pan, A., Nadora, D., Gahoonia, N., Chaudhuri, R. K., Burney, W., Thacker, S., Shakhbazova, A., Subramanyam, C., Chambers, C. J., & Sivamani, R. K. (2023). Randomized Double-Blind Placebo-Controlled Supplementation with Standardized Terminalia chebula Fruit Extracts Reduces Facial Sebum Excretion, Erythema, and Wrinkle Severity. Journal of clinical medicine, 12(4), 1591. https://doi.org/10.3390/jcm12041591
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Maruki-Uchida, H., Sai, M., Yano, S., Morita, M., & Maeda, K. (2020). Amazake made from sake cake and rice koji suppresses sebum content in differentiated hamster sebocytes and improves skin properties in humans. Bioscience, biotechnology, and biochemistry, 84(8), 1689–1695. https://doi.org/10.1080/09168451.2020.1756734
Chipchanged the channel name: Supplements related to sebum reduction22/07/2024 10:29 PM
